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A 24 h fasting period of WT or ob/ob mice, upregulated PPAR and PPAR-target genes related to mitochondrial (medium- and long-chain acyl-CoA dehydrogenases), peroxisomal (acyl-CoA oxidase (ACOX) 1 and enoyl-CoA hydratase), and cytochrome-mediated (CYP4A1 and CYP4A3) FAO [85]

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Other D2 receptor antagonists, including domperidone, may improve symptoms to a comparable extent to metoclopramide [70]

Most notably, patients reported not just a body weight loss but also improvements in their overall health markers, including blood sugar levels, cholesterol profiles, and reductions in risk factors for chronic diseases and severe cardiovascular conditions