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All references to research relate strictly to non-clinical scientific investigation

Critically, elevated fasting circulating BCAAs in obesity and insulin resistance primarily indicate impaired peripheral catabolic disposal and altered inter-organ flux, not simply excessive dietary intake

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Integrating ChIP-seq, HiC, and PRO-seq datasets, we revealed broad functional binding of NRF2 at enhancer elements, including NRF2-dependent enhancer-derived RNA (eRNA) synthesis and extensive linkages between NRF2 target promoters and enhancers