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HA has been shown to modulate ocular surface inflammation through interactions with CD44 and other cell-surface receptors, thereby influencing leukocyte trafficking and reducing the expression of pro-inflammatory cytokines and chemokines ( One of the most intriguingly and seemingly counterintuitive findings of our study was the posttreatment surge in tearfluid cytokines (IFN-2, IFN-, TNF-, IL-6, IL-23 and IL-33) that accompanied clinical improvements in tearfilm stability and corneal integrity

10.1186/s40001-025-02524-4 Eur J Med Res

(2016) 5:e002621

Questions remain about long-term adherence, weight regain after discontinuation of treatment, and the functional implications of the loss of muscle and bone mass