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Therapeutic implications The biology argues against indiscriminate antioxidant loading. More promising are source- and compartment-targeted strategies (e.g., NOX isoform modulation, mitochondrial quality control, ER stress tuning), buffer re-balancing (GSH/thioredoxin systems), iron management to suppress Fenton chemistry and lifestyle interventions that reshape ROS tone without blunting adaptive signalling

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Sadly, doctors will often stop treatment when B12 levels look high

In this article, we explore the history and practice of using vitamin drips to treat migraines, along with some of the scientific evidence currently available