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In a renal proximal tubule-specific Tsc1 gene-knockout mouse model, downregulated AMPK phosphorylation was observed in the enlarged kidneys, which also exhibited aberrant proliferation of proximal tubule cells, renal interstitial inflammation, and fibrosis

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(47) suggested that Bacteroidetes did not produce TMA, and Wang et al

Larger, longer-term randomized controlled trials in a variety of demographics are required to make solid recommendations and elucidate the effectiveness and safety of customized supplementation plans