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Established microvascular complications of diabetes mellitus at baseline included diabetic nephropathy (7%), retinopathy (8%), or neuropathy (16%)

The standard therapeutic dose is 0.51.0mL subcutaneously once weekly, injected into the lower abdomen or lateral thigh with a 25G or 27G needle

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In the foundational mouse study, MOTS-c prevented diet-induced obesity and reversed insulin resistance without changes in food intake or exercise (Lee et al