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In target tissues, such as the liver and the brain, T 4 (the most abundant circulating thyroid hormone) can be converted to T 3 by selenium-containing enzymes known as iodothyronine deiodinases (DIOs) ( Figure 1

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Moreover, the proteins produced by LAB, like cytokines with immunomodulatory effect or vaccine antigens [23, 24], do not require an intracellular protein delivery to exert a therapeutic effect and frequently act directly in situ on the intestinal mucosa, not requiring to reach organs/tissues that are distant from the site of LAB production