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Having genetic markers associated with lower baseline bone density or faster bone turnover does not predict exact GLP-1 outcomes, but can support a more personalized monitoring strategy

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Co-authors of the research, Dinabel Peralta-Reich, MD, and Alexandra Filingeri DCN, RCN, explained the key findings to Medical News Today: This study measured body compositionspecifically body fat mass (in pounds), muscle mass (in pounds), and total body weight (in pounds)in patients at baseline, 3 months, and 6 months while taking GLP/GIP weight loss medications

AMPK activation: Enhances glucose uptake into muscle and fat cells Improves insulin sensitivity Reduces glucose production in the liver Influences lipid metabolism Berberine also modulates gut microbiome composition, which may contribute to its metabolic effects through mechanisms still being elucidated 8 Zhang, X