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Experimental studies have shown that GLP-1RAs have a protective effect by modulating neuroinflammation, oxidative stress, mitochondrial function and autophagy, as well as protein conformation alterations

According to the classification by Baran[27], the nail pigmentation in LHS is mainly categorized into three types: A single 1 to 2 mm wide longitudinal streak, a double 2 to 3 mm wide longitudinal streak on the lateral portion of the nail plate, and homogeneous pigmentation of the radial or ulnar half of the nail plate

It is investigated in experimental models for its interaction with growth factor signaling, angiogenesis-related mechanisms, and cytoprotective processes

The therapy often includes Habit Reversal Training (HRT), which teaches alternative behaviors to replace hair-pulling