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For patients and clinicians, the practical takeaway is that retatrutide's side effect profile is broadly similar to existing peptide-based obesity treatments, with the addition of dysesthesia as a novel but generally manageable consideration

The effects are comparable to prescription-strength hydroquinone without all of the concerns of hydroquinone, such as irritation and having to rotate off of it, making it a good choice for sensitive skin, says board-certified dermatologist Dr

A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors

Healthy Aging 4 , 255263 (2017)