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23 Supplementation of 1 mg daily is recommended for patients with specific risk factors (e.g., bariatric/gastric surgery patients, those with severe malnutrition, chronic alcohol use, chronic hemolytic anemia and conditions with high cell turnover, and use of antimetabolite medications such as methotrexate)

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582,583,584 Catecholamines can induce glycogenolysis by activating glycogen phosphorylase (GP) and enhance gluconeogenesis by activating fructose-1,6-bisphosphatase (FBPase) to increase fructose-6-phosphate levels and PEPCK to promote the synthesis of phosphoenolpyruvate