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The most common side effects are injection-site soreness (41%, lasting 24-36 hours), mild nausea (12-15%, lasting 4-8 hours), and skin flushing (8-10%, lasting 10-30 minutes)
concurrent tobacco smoking further augments thrombotic risk, and careful monitoring is advised when estrogens are co-administered with thyroid hormones, corticosteroids, or anticoagulants due to possible alterations in binding protein levels and pharmacodynamic response
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