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The STEP trials evaluated semaglutide and showed average weight reductions of around 15% over 68 weeks, while SURMOUNT trialsfocusing on tirzepatide, a dual GIP/GLP-1 receptor agonistdemonstrated even greater reductions, with participants losing up to 21% of their body weight over 72 weeks (Note: GIP = Glucose-dependent insulinotropic polypeptide)

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Clinicians should carefully assess all nails for atypical features that may indicate a developing periungual melanoma and prompting a referral to a dermatologist for evaluation (Box 7-1)

Risks and Side Effects of BPC-157 While many anecdotal reports from athletes and biohackers praise BPC-157s healing potential, its safety profile isnt fully established in humans due to the lack of long-term clinical trials