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As mentioned before, Pycnogenol was shown to have potent antioxidant efficacy and protects lipids, DNA and proteins from oxidation within the body in addition to its ability to increase blood antioxidant capacity ( Another property of Pycnogenol explaining its effect of increased performance is the improved tissue perfusion by enhancing microcirculation ( 3 Discussion Pycnogenol s unique composition of bioactive substances with diverse biological targets explains its efficacy on a broad range of human health conditions

Int J Mol Sci 22:10226

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Additionally, NIX has been identified as a substrate for Parkin, facilitating Parkin/PINK1-dependent mitophagy (Gao et al., 2015)