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Therefore, the neuroprotective effect of SIRT1 is mainly mediated by activation of neurogenesis, synaptic plasticity, improvement of mitochondrial function, regulation of BBB permeability with inhibition of oxidative stress, and accumulation of -synuclein and tau proteins (Zhang et al

If adenosine or homocysteine accumulates, the reaction may favor re-formation of SAH, which inhibits methyltransferases

doi: 10.1186/s40168-019-0719-1 99 SoJ-SLeeCGKwonHKYiHJChaeCSParkJAet al

Predominantly classified under the NREM sleep category, SWS is characterized by its distinctive low-frequency, high-amplitude delta brainwaves, as observed in electroencephalogram (EEG) recordings