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This accumulation increases the demand on protein quality control systems, ultimately activating the UPR-a central signalling pathway that restores ER homeostasis (Iwata and Koizumi 2012

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Jakubowicz-Gil J, Rzeski W, Zdzisinska B, Dobrowolski P, Gawron A (2008) Cell death and neuronal arborization upon quercetin treatment in rat neurons

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