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A p-value less than 0.05 was considered statistically significant, indicating a meaningful difference in treatment efficacy

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Although NNMT may affect nicotinamide levels and NAD+ pathways, the real impact in the body is still unclear

While RCTs remain the gold standard for intervention assessment, observational studies provide complementary evidence, especially when using objective biomarkers such as serum Vitamin B12, MMA, and homocysteine