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Production of butyrate by gut commensals contributes to immunity regulation of the host by inducing the differentiation of colonic and systemic regulatory T cells 5,6 and has an important epigenetic effect on gut epithelial cells by inhibiting histone deacetylase (HDAC) 7,8

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Second, for the validity of study results, we adopted sophisticated analytic procedures to estimate the treatment effectiveness and healthcare costs, including NNT measures derived from the survival analysis with adjustment for imbalanced baseline characteristics between study groups, and downstream healthcare costs estimated from a regression analysis with adjustment for baseline costs

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