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These results suggest that NAFLD is caused by both increased lipid storage (from circulating fatty acid uptake and de novo lipogenesis) and decreased lipid removal (via fatty acid oxidation or VLDL-triglycerides secretion)

On the positive side, selective GLP-1 receptor agonism avoids the glucagon receptor-mediated hepatic glucose output and potential ketogenic effects that complicate dual agonist approaches

The EMAs human medicines committee (CHMP) acknowledged that Mounjaro improves OSA in patients with obesity

The article highlights that Semaglutide monotherapy provides statistically significant and clinically meaningful weight loss, with the majority of patients experiencing a reduction of 5% or more of their body weight