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Researchers have found that only around 40% of people are able to produce urolithin A due to differences in individual gut microbiomes.6 Fortunately, other studies have found that the remaining 60% of people can overcome that limitation through supplementation.12 Most of the potential benefits of urolithin A are attributed to the compounds effects on mitophagy.7 This is when your body cleans up damaged or excess mitochondria,8 then replaces them with new, healthy ones to maintain mitochondrial homeostasis.14 As you age, the rate and effectiveness of the mitophagy process decrease
Hence, it is important to always start with low concentrations and then make your way up to higher, more effective, and safe formulations
Touyz RM
In a recently published animal study, malondialdehyde (MDA, a marker of lipid peroxidation) is decreased after riboflavin administration in rat model of renal toxicity (Reference Alhazza, Hassan and Ebaid23)
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