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Liver-expressed antimicrobial peptide 2 (LEAP-2), the endogenous noncompetitive allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a), was recently identified as a key endocrine factor regulating systemic energy metabolism

The proposed mechanism involves transdermal absorption , whereby the active compound penetrates the skin's outer layers (stratum corneum) and enters systemic circulation via dermal capillaries

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The next stage of this work will be to test these associations in further cohorts, including from different countries. This work was supported by Cancer Research UK, UK Medical Research Council, Wellcome, and a Nuffield Department of Population Health Early Career Research Fellowship grant