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Hypoglycemia It is well known that GH, together with glucagon, cortisol, and epinephrine, display counterregulatory actions protecting from hypoglycemia, and that its excess may have a diabetogenic role as seen in subjects suffering from acromegaly ( In a double-blind RCT in T2D patients, a single dose of the GLP-1 analogue albiglutide did not impair the -cell response or GH secretion when blood glucose was clamped in the hypoglycemic range ( 2460 h), FFAs represent the key fuel of whole-body energy homeostasis

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