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The balance between the reduced and oxidized forms of glutathione is a central component in maintaining cellular redox state (Meister, 1995)

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11 Although low concentrations of PPA may be beneficial, humans with impairments in PPA metabolism (that is, propionic or methymalonic acidemia, holocarboxylase, biotinidase or B12 deficiency, valproate or ethanol exposure) exhibit neurodevelopmental conditions with behavioral and biochemical similarities to ASD

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