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Physiotherapy plays a vital rolebut there are limits depending on the cause of the locking: Physiotherapy can help if: Locking is due to muscle guarding , pain , or swelling (pseudo-locking) Symptoms are mild or intermittent The tear is stable and not displaced Physiotherapy cannot fix : True mechanical locking caused by a displaced meniscus fragment Bucket-handle tears that are physically obstructing joint movement In those cases, urgent surgical referral is necessary to avoid further damage

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Preclinical evidence supports the role of GLP-1RAs in alleviating neuropathic pain through the modulation of microglial activity, inflammatory cytokine production and -endorphin release [63, 65, 68, 7074]