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Supported by robust clinical trial data and real-world evidence, these approaches address the multifaceted nature of NPDR, offering hope for preventing vision loss and systemic complications in T1DM and T2DM patients

Polyamines are involved in cell division and proliferation, regulation of gene expression for cell survival, facilitation of DNA and protein synthesis, apoptosis and oxidative stress control, angiogenesis, and cell-to-cell communication (Lenis et al., 2017)

Sustained dysregulation of iron and glutathione homeostasis induces chronoferroptosis, a persistent ferroptotic adaptation in neuronal cells

Galland and I