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A Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) enrolled 338 adults with obesity and reported mean body weight reductions of up to approximately 24% over 48 weeks at the highest dose studied (12 mg weekly)

The peptide mice were reported to have experienced considerable weight loss, suggesting that the peptide may not depend on the lipolytic receptors to exert any action

Noticeable results become apparent within weeks of starting treatment in Lansing

That matters more than it sounds: the injectable form sidesteps the gut absorption issues that make B12 pills hit-or-miss for the very people who tend to need it most