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Reactive oxygen species (ROS), together with reactive nitrogen species (RNS), represent the most important prooxidants whose excessive accumulation leads to oxidative stress (OxS) and molecular damage ( ROS are crucial in thyroid function because they are essential in the initial stages of thyroid hormone synthesis during iodide oxidation ( Aerobic organisms have evolved multiple antioxidant and repair systems for protection against OxS

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Fluoxetine administration to treat depression during pregnancy has been shown to induce greater changes in gene expression in the placenta of male infants than in that of female infants, emphasizing its sex-specific effects (Staal et al., 2024)