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I tried to combat it by eating healthy, staying active and trying to stick with my new healthy habits I formed [while] on the GLP-1." The expectant mother said she gained back 20 pounds within the first three months of her pregnancy, which "significantly affected" her mental health

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These mechanisms indicate that decrements in GLP-1R efficacy are not merely the result of receptor downregulation but are rooted in a fundamental disruption of the intracellular environment, driven by organelle stress and lipotoxic signaling

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