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In keratinocytes, 1,25(OH)D suppresses Nigericin-induced ROS production by activating antioxidant pathways such as NRF2HO-1, thereby inhibiting NLRP1 inflammasome activation in Nigericin-stimulated normal human epidermal keratinocytes (NHEKs) [192]

After menopause, estrogen levels drop sharply, leading to: Increased osteoclast activity Accelerated bone resorption Rising urinary DPD levels This makes DPD testing particularly valuable for postmenopausal women , helping identify those at highest risk for rapid bone loss

Promotes quality improvement: They work to improve the quality of health and social care services by providing advice and tools to healthcare professionals and organizations

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