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This metabolic shift is highly problematic because anaerobic glycolysis produces only a fraction of the ATP generated by aerobic respiration, and it creates toxic byproducts in the process
The Phase 2/3 LIFT-AD trial (NCT04488419), evaluating once-daily subcutaneous fosgonimeton 40 mg versus placebo in 312 participants with mild-to-moderate Alzheimers disease over 26 weeks, failed its primary endpoint (Global Statistical Test composite of ADAS-Cog11 and ADCS-ADL23) and its key secondary endpoints when results were announced in September 2024
Lets say I have a patient who I know is a slow metabolizer
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