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Clinical evidence confirms anti-IL-6 targeted therapy rapidly alleviates CRF, while anemia correction with erythropoietin (EPO) alone has limited efficacy, further validating the central role of chronic inflammation (Modak et al

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While this may facilitate the entry of immune cells to fight infectious agents, it also provides an avenue for luminal contents including commensal microbes, pathogens, and dietary components, to bypass the intestinal epithelium and enter systemic circulation