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Regarding glucose-metabolism, two studies found that GLP-1(9-36), GLP-1 (7-36) and Liraglutide significantly inhibited insulin-stimulated glucose uptake [12, 13], with Liraglutide showing a dose dependent inhibition, with a maximum at a concentration of 1000 nM [12, 13]

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MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide encoded by a short open reading frame within the mitochondrial 12S rRNA gene one of the first known peptides encoded by mitochondrial rather than nuclear DNA