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In the SN neurons of PD, the expression of Nrf2 in the nucleus is enhanced, and the expression of its signature proteins NQO1 and HO-1 is upregulated, suggesting a brain protective effect mediated by Nrf2

The mechanisms of lipid and glucose metabolism disorders in MASLD involve multiple factors, among which IR plays a key role, manifesting as reduced glucose utilization (100)

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In patients with chronic constipation, the presence of depressive symptoms renders constipation symptoms more refractory and difficult to treat