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Acknowledgements We thank Colleen McHugh and Harriet Pratley for the generation of GspD/PilQ antisera, Jos Muoz-Dorado for providing plasmids for copper-inducible gene expression, Tm Mignot, Emilia Mauriello, and Penelope Higgs for providing carbohydrate deletion strains, Daniel Bollschweiler, Florian Beck, and Harald Engelhardt (MPI of Biochemistry, Martinsried) for their help with averaging the negatively stained A
Pharmacokinetic studies showed that intratracheal administration of the formulation increased the area under the curve (AUC) by 4.3 times and the C max by 9.11 times compared to intragastric delivery, highlighting its rapid absorption and enhanced lung bioavailability [222]
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