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The Z-curves can fall into one of four categories: surpassing both the conventional and TSA thresholds (true positive, indicating the effectiveness of combination therapy), surpassing only the conventional threshold (false positive), falling below both the TSA and conventional thresholds without reaching the required sample size (false negative), and falling below both the TSA and conventional thresholds but having reached the required sample size (true negative, favoring the comparator arm)

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Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ (2003) Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis