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Results KAT6A mutations cause a decrease in histone H3 lysine 23 (H3K23) acetylation in human cells and mice To determine the effects of mutation of the KAT6A gene on histone acetylation, we generated human HEK293T cells carrying six different KAT6A variants observed in individuals with ARTHS using CRISPR/Cas9 and homology-directed repair (Tables S1, S2, and S3)

Vitamin C excels at boosting collagen production that reduces fine lines

Fat-soluble vitamins like A and D are harmful in excess, because they build up in fat stores

So while supplementing with exogenous GH in GH deficient individuals may normalize lean body mass to bodyfat ratios, the increase in lean body mass is due to water retention associated with increased collagen formation, whole body (not muscle) protein synthesis, and changes in kidney regulation of water and electrolytes, not from actual muscle tissue