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As previously stated in this review, GSH is the most abundant intracellular antioxidant and plays major roles in the antioxidant defense system and maintenance of redox homeostasis in both the PNS and CNS ( Specifically in regard to T lymphocytes, GSH is necessary for T cell phenotype and effector functions

Curcumin has also been shown to induce ferroptosis in HCT-8 CRC cells exhibiting characteristics of ROS overload 13

Allergic or hypersensitivity reactions (rare) May occur in response to peptide compounds or formulation preservatives

Kumar and Bachhawat hypothesized that this leads to the combination of cytosolic cysteine and glutathione depletion, which activates the ATP-depleting futile 5-oxoproline cycle