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Further, overproduction of free radicals have also been shown to occur due to spontaneous breakdown (autoxidation) and/or excessive metabolism by monoamine oxidase of adrenaline, noradrenaline and dopamine, which can further overwhelm the brains antioxidant systems (Cohen, 1984

Targeting Senescent Cell Anti-Apoptotic Pathways (SCAPs) The development of senolytics to eliminate senescent cells (SnCs) is one of the strategies used to treat age-related diseases

The importance of gut microbiota in early life and brain development is demonstrated by animal studies showing that maternal separation of neonates does not only lead to a dysbiotic state of the microbiota that persists into adulthood, but also results in long-term cognitive and behavioral deficits (159)

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