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Goode RK, Crawford BE, Callihan MD, Neville BW: Oral melanoacanthoma: review of the literature and report of ten cases

Further research is required to fully characterize its mechanisms of action and broader applications within biomedical science

Thus, the most accurate interpretation is not safe, but rather no stable teratogenic signal identified to date, with evidence still insufficient for a safety conclusion (132). In clinical counseling, this distinction matters: inadvertent early exposure should generally prompt individualized risk communication and obstetric follow-up, not automatic reassurance and not automatic inference of major harm

However, changes in intestinal microbiota are also described in some extraintestinal diseases, such as type 2 diabetes [19], rheumatoid arthritis [20], systemic lupus erythematosus [21], and other autoimmune diseases