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Most researchers assume that because peptides are endogenous signaling molecules and antidepressants are small-molecule drugs, they operate in separate pharmacological spaces

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In addition to its potential influence on sleep patterns, DSIP appears to influence levels of corticotropin, inhibit the production of somatostatin, reduce stress hormone secretion, maintain normal blood pressure, alter sleep patterns and also may impact pain perception

MRI findings in LS often help elucidate the underlying etiology, with classic abnormalities involving the basal ganglia, particularly the bilateral putamen, periaqueductal gray, and brainstem (40)