glp-1 drinking medications get at the heart of addiction: study – WashU Medicine GLP-1 shifts alcohol market dynamics

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doi: 10.1093/qjmed/hct051

Those two signals can feed the same GH pulse from different angles

To investigate the functional role of the R6 region in the SIRT1 promoter, a series of luciferase reporter constructs was obtained from VectorBuilder (USA), including a promoterless basic vector, a construct containing the full-length human SIRT1 promoter, including the R6 site, and promoter fragments corresponding to regions upstream and downstream of the R6 site that lack the R6 region (vector IDs: VB260105-1480rwj, VB260105-1503wsw, VB260105-1505cps, and VB260105-1513uay)