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This adaptive change could contribute to tolerance by increasing MOR signaling through nonagonist-bound receptors or by enhancing MOR desensitization if constitutively active receptors are susceptible to the same desensitizing and internalizing processes as agonist-bound receptors

Moving forward, there is much more to learn and explore, with new information continually emerging, enhancing our understanding and potentially leading to the release of a second edition of my book to share these insights

That sounds like science fiction, but researchers at the University of Wisconsin-Madison have taken an intriguing step in that direction

Handling & Use (Laboratory Settings) Intended Use: Research use only