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One document warns that a peptide, MOTS-c, marketed online to promote the metabolism of fatty acids in the liver, insulin resistance and weight loss, hasn't been proven safe for human use in compounded drugs

Adv Pharmacol Toxicol 20(2):25 Han H, Hu S, Hu Y, Liu D, Zhou J, Liu X, Ma X, Dong Y (2023) Mitophagy in ototoxicity

H. Penget al., Thymosin-4prevents cardiac rupture and improves cardiac function in mice with myocardial infarction, American Physiological Society, Sep. 2014. doi: 10.1152/ajpheart.00129.2014

During the meeting, several members questioned whether FDA placed too much emphasis on the lack of randomized clinical trials and too little weight on clinical experience and other available evidence, while members opposing the recommendations argued the committee should rely on stronger scientific evidence rather than growing consumer demand