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Disruptions in the IGF-I signalling pathway also result in reduced intrauterine growth as observed in mice deficient in Akt1 (Cho et al ., 2001), insulin receptor substrate-1 (IRS-1) and IRS-2 (Araki et al ., 1994

The urinary antiproliferative factor (APF), which has been recently identified in the context of IC, acts to hinder cell growth and disrupts the repair of the damaged or worn-away urothelium, leading to alterations in the barrier function of the bladder lining (Sant, 2002)

The gap between theoretical potential and practical results drives continued experimentation with dosing protocols

It has not been demonstrated to produce any benefit in humans, and the components are not interchangeable with prescription products