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Alshamsi F, Pathan A, Yasin J, Sharma C, Alshemsi HA, Alblooshi A, et al

Even with a healthy diet and exercise routine, many of us are walking around with nutrient deficiencies we dont even know about, leaving us feeling tired, foggy, sluggish, or simply not at our best

In contrast, SAGE-DM is not a cluster-defined or statistically derived phenotype, but a mechanistically oriented framework emphasizing the role of aging biology rather than clinical clustering

A commenter recommended updating the eligibility definition to rely on data elements available in near real time (for example, use of anesthesia or sedation) or extending the timeline for survey administration