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J Biol Chem (2005) 280(45):3748994.10.1074/jbc.M506967200 182 del RinconJPIidaKGaylinnBDMcCurdyCELeitnerJWBarbourLAet alGrowth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance
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Innovative approaches that enhance spatial precisionsuch as physical spacers, customized applicators, or biomaterial-based interventionshave the potential to mitigate these dose distribution limitations, allowing for safe intensification of tumor-targeted radiation without increasing toxicity to surrounding organs
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