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glutathione) to xenobiotics and/or phase I products to produce more hydrophilic products

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These animals closely replicate clinical features seen in people living with MC4R pathway deficiency, including: Excessive food intake Rapid fat accumulation Fatty liver disease Elevated cholesterol levels Early insulin resistance Under normal physiological conditions, hunger regulation relies heavily on signalling cascades such as the POMCMC4R and leptinMC4R pathways, which transmit satiety signals as the stomach approaches fullness