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4.1 Exendin 4-based agents Exendin-4, a 39-amino acid peptide with 53% sequence homology to human GLP-1 [ Figure 2 ], was originally isolated from Heloderma suspectum lizard venom by using an amino acid sequencing assay targeting peptides with an amino-terminal histidine residue (His 1 ) (83)

It was developed by Eli Lilly and entered the published Phase 2 program in 2023 with three parallel disease contexts: obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease

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