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Some studies have explored whether GLP-1 RAs could be used as a standalone treatment or in combination with other therapies for depression

[4] [5] Additional contributing factors include: Sleep disturbances and night sweats disrupting metabolic regulation Reduced physical activity due to fatigue or joint discomfort Psychological factors including stress, mood changes, and emotional eating Changes in insulin sensitivity Weight changes during the menopausal transition vary considerably between individuals

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3.2 Therapeutic potential in obesity Although the incretin effects of GIPR undoubtedly play a crucial role in preventing postprandial glucose excursion, there is still intensive debate on whether the GIPR should be activated or inhibited for the treatment of obesity