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Research in animal models shows activity at approximately 0.5mcg/kg, though human protocols typically use standardized doses in the 1-3mg range regardless of body weight

[DOI] [PubMed] [Google Scholar] 169.Smart D, Sabido-David C, Brough SJ, et al

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In addition to the conditions mentioned above, several risk factors increase the likelihood of B12 deficiency: Smoking Alcohol abuse Endocrine-related autoimmune disorders (such as diabetes or thyroid disorders) Gastrointestinal disorders like Crohns disease History of gastric bypass surgery or other stomach-altering surgeries Optimize Your Health